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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473 Species: Mus musculus RGD Object: Gene Symbol: Nqo1 Name: NAD(P)H dehydrogenase, quinone 1

Acc ID: CHEBI:7719 Term: ochratoxin A Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid. It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum. CasRN: 303-47-9 Chemical ID: MESH:C025589

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:2503	6480464	CTD	ochratoxin A results in decreased expression of NQO1 mRNA	PMID:19717638
multiple interactions	ISO	RGD:2503	6480464	CTD	[cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased expression of NQO1 protein]	PMID:17110534
decreases expression	ISO	RGD:2503	6480464	CTD	ochratoxin A results in decreased expression of NQO1 protein	PMID:17110534
increases expression	ISO	RGD:735868	6480464	CTD	ochratoxin A results in increased expression of NQO1 mRNA	PMID:17316727