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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620854
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dusp5
Name: dual specificity phosphatase 5
Acc ID: CHEBI:76995
Term: alpha-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).
Chemical ID: MESH:C011512
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dusp5multiple interactionsISODUSP5 (Homo sapiens)6480464CTDalpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of DUSP5 mRNA]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of DUSP5 protein]PMID:19578757
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