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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:76591
Term: (25R)-cholest-5-ene-3beta,26-diol
Definition: A 26-hydroxycholesterol in which the 25-position has R-configuration.
Chemical ID: MESH:C076996
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects response to substanceEXP 6480464CTDESR1 protein affects the susceptibility to 27-hydroxycholesterolPMID:17873880
Esr1multiple interactionsEXP 6480464CTDESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]PMID:17873880
Esr1increases degradationISOESR1 (Homo sapiens)6480464CTD27-hydroxycholesterol results in increased degradation of ESR1 proteinPMID:17872378
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR1 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR1 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased activity of ESR1 protein]PMID:17872378 PMID:17873880
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