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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620196
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp13
Name: matrix metallopeptidase 13
Acc ID: CHEBI:7575
Term: nimodipine
Definition: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Chemical ID: MESH:D009553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp13multiple interactionsEXP 6480464CTDNimodipine promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]PMID:27095094
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