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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520 Species: Rattus norvegicus RGD Object: Gene Symbol: Drd2 Name: dopamine receptor D2

Acc ID: CHEBI:7575 Term: nimodipine Definition: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm. CasRN: 66085-59-4 Chemical ID: MESH:D009553

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Nimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein]	PMID:12186780