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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619930
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb11
Name: ATP binding cassette subfamily B member 11
Acc ID: CHEBI:7550
Term: nicardipine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
Chemical ID: MESH:D009529
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb11decreases activityISOABCB11 (Homo sapiens)6480464CTDNicardipine results in decreased activity of ABCB11 proteinPMID:20829430 PMID:23956101 PMID:24014644
Abcb11multiple interactionsISOABCB11 (Homo sapiens)6480464CTDNicardipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]PMID:24014644
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