Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	3889
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Tp53
Name:	tumor protein p53

Acc ID:	CHEBI:75142
Term:	N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition:	A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID:	MESH:C072553

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Tp53	increases expression	EXP		6480464	CTD	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TP53 protein modified form	PMID:26612707
Tp53	increases ubiquitination	EXP		6480464	CTD	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of TP53 protein	PMID:18463101
Tp53	multiple interactions	EXP		6480464	CTD	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Acetaminophen results in increased degradation of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of and results in increased expression of TP53 protein	PMID:16330492 PMID:18463101 PMID:26612707
Tp53	increases expression	ISO	TP53 (Homo sapiens)	6480464	CTD	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TP53 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TP53 protein	PMID:10837373 PMID:31806706 PMID:35821281
Tp53	multiple interactions	ISO	TP53 (Homo sapiens)	6480464	CTD	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Capsaicin results in increased degradation of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Chlorpyrifos results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of TP53 protein mutant form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of TP53 protein	PMID:18951928 PMID:19699254 PMID:20530418 PMID:21454520 PMID:27129209 PMID:27993609

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