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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HMOX1 proteinPMID:25824035
Hmox1multiple interactionsEXP 6480464CTD[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in decreased expression of HMOX1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in decreased expression of HMOX1 protein]PMID:25824035
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HMOX1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HMOX1 proteinPMID:12441344 PMID:18835339
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HMOX1 mRNAPMID:30186748
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA]PMID:18835339
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of HMOX1 mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of HMOX1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in increased expression of HMOX1 mRNA]; HMOX1 protein inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HMOX1 mRNA]PMID:18550526 PMID:25824035 PMID:30186748 PMID:33434570
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