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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620248
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb4
Name: ATP binding cassette subfamily B member 4
Acc ID: CHEBI:7494
Term: nefazodone
Definition: A N-alkylpiperazine that has formula C25H32ClN5O2.
Chemical ID: MESH:C051752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb4increases expressionEXP 6480464CTDnefazodone results in increased expression of ABCB4 mRNAPMID:24136188
Abcb4decreases activityISOABCB4 (Homo sapiens)6480464CTDnefazodone results in decreased activity of ABCB4 proteinPMID:28437613
Abcb4multiple interactionsISOABCB4 (Homo sapiens)6480464CTD[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone] results in increased expression of ABCB4 mRNAPMID:33819548
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