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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:74460
Term: 5-chloro-7-iodoquinolin-8-ol
Definition: A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Chemical ID: MESH:D007464
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDClioquinol results in decreased expression of VEGFA mRNAPMID:19502547
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDClioquinol results in increased expression of VEGFA mRNA; Clioquinol results in increased expression of VEGFA proteinPMID:16973622 PMID:19502547
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTDHIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein]PMID:19502547
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