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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:73390
Term: promegestone
Definition: A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.
Chemical ID: MESH:D011397
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgraffects localizationEXP 6480464CTDPromegestone affects the localization of PGR proteinPMID:16020483
Pgraffects bindingISOPGR (Homo sapiens)6480464CTDPromegestone binds to PGR proteinPMID:23765520
Pgrincreases activityISOPGR (Homo sapiens)6480464CTDPromegestone results in increased activity of PGR proteinPMID:15103026 PMID:20008677 PMID:30951782
Pgrincreases uptakeISOPGR (Homo sapiens)6480464CTDPGR protein results in increased uptake of PromegestonePMID:21795739
Pgrmultiple interactionsISOPgr (Mus musculus)6480464CTDPGR protein promotes the reaction [Promegestone results in increased expression of FSHB mRNA]PMID:16675544
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTD1,1-bis(4-hydroxyphenyl)cyclohexane inhibits the reaction [Promegestone results in increased activity of PGR protein]; Bortezomib inhibits the reaction [Promegestone results in increased activity of PGR protein]; carfilzomib inhibits the reaction [Promegestone results in increased activity of PGR protein]; Decitabine inhibits the reaction [Promegestone results in increased activity of PGR protein]; fenpyroximate inhibits the reaction [Promegestone results in increased activity of PGR protein]; fluoxastrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]; kresoxim-methyl inhibits the reaction [Promegestone results in increased activity of PGR protein]; methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]; metoprine inhibits the reaction [Promegestone results in increased activity of PGR protein]; Mifepristone inhibits the reaction [methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]]; picoxystrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]; Proflavine inhibits the reaction [Promegestone results in increased activity of PGR protein]; Promegestone promotes the reaction [ARID1A protein binds to PGR protein]; Promegestone promotes the reaction [SMARCE1 protein binds to PGR protein]; pyrachlostrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]; pyridaben inhibits the reaction [Promegestone results in increased activity of PGR protein]; Rotenone inhibits the reaction [Promegestone results in increased activity of PGR protein]; ST 1481 inhibits the reaction [Promegestone results in increased activity of PGR protein]; trifloxystrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]; U 0126 inhibits the reaction [methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]]; Vorinostat inhibits the reaction [Promegestone results in increased activity of PGR protein]; ZNF366 protein inhibits the reaction [Promegestone results in increased activity of PGR protein]PMID:15103026 PMID:18486176 PMID:19609353 PMID:20008677 PMID:30818834 PMID:30951782
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