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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:72631
Term: 3-phenoxybenzoic acid
Definition: A phenoxybenzoic acid in which the phenoxy group is meta to the carboxy group. It is a metabolite of pyrethroid insecticides.
Chemical ID: MESH:C017618
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases activityISOEsr1 (Rattus norvegicus)6480464CTD3-phenoxybenzoic acid results in decreased activity of ESR1 proteinPMID:20410157
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTD3-phenoxybenzoic acid inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]PMID:24388911
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD3-phenoxybenzoic acid inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]PMID:24388911
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