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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin-dependent kinase 1
Acc ID: CHEBI:72564
Term: temozolomide
Definition: An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.
Chemical ID: MESH:C047246
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1affects phosphorylationISOCDK1 (Homo sapiens)6480464CTDtemozolomide affects the phosphorylation of CDK1 proteinPMID:23522185
Cdk1increases expressionISOCDK1 (Homo sapiens)6480464CTDTemozolomide results in increased expression of CDK1 mRNAPMID:31758290
Cdk1multiple interactionsISOCDK1 (Homo sapiens)6480464CTD[temozolomide co-treated with resveratrol] results in decreased phosphorylation of CDK1 protein; AKT1 protein inhibits the reaction [temozolomide results in increased phosphorylation of and results in decreased activity of CDK1 protein]; temozolomide results in increased phosphorylation of and results in decreased activity of CDK1 proteinPMID:15930307 PMID:23522185
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