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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldha
Name: lactate dehydrogenase A
Acc ID: CHEBI:71417
Term: procarbazine
Definition: A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Chemical ID: MESH:D011344
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldhaincreases mutagenesisISOLdha (Mus musculus)6480464CTDProcarbazine results in increased mutagenesis of LDHA genePMID:7534515
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