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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:70778
Term: GW 7647
Definition: A monocarboxylic acid that is 2-(phenylsulfanyl)isobutyric acid in which the phenyl group is substituted at the para- position by a 3-aza-7-cyclohexylhept-1-yl group in which the nitrogen is acylated by a (cyclohexylamino)carbonyl group.
Chemical ID: MESH:C453899
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3increases expressionEXP 6480464CTDGW 7647 results in increased expression of NR1I3 mRNAPMID:19631232
Nr1i3multiple interactionsEXP 6480464CTDGW 7647 promotes the reaction [Phenobarbital results in increased expression of NR1I3 mRNA]PMID:19631232
Nr1i3multiple interactionsISONR1I3 (Homo sapiens)6480464CTD[GW 7647 co-treated with Oleic Acid] results in decreased expression of NR1I3 mRNAPMID:30611723
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