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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:6904
Term: metoprolol
Definition: A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Chemical ID: MESH:D008790
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4affects metabolic processingISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 protein affects the metabolism of Metoprolol; CYP2D6 protein polymorphism affects the metabolism of MetoprololPMID:11823760 PMID:15286053 PMID:15327588
Cyp2d4affects response to substanceISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 gene affects the susceptibility to Metoprolol; CYP2D6 gene polymorphism affects the susceptibility to MetoprololPMID:12172215 PMID:18648788 PMID:18784654 PMID:19094446
Cyp2d4increases metabolic processingISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 protein results in increased metabolism of MetoprololPMID:10848718 PMID:12464242 PMID:18979093 PMID:19230594 PMID:24894748
Cyp2d4multiple interactionsISOCYP2D6 (Homo sapiens)6480464CTD[Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased degradation of Metoprolol; [Paroxetine results in decreased activity of CYP2D6 protein] which results in increased susceptibility to Metoprolol; [Terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]; CYP2D6 gene polymorphism affects the reaction [Amiodarone results in increased abundance of Metoprolol]; Hydroxychloroquine inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]; YM 758 inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]PMID:10470702 PMID:10848718 PMID:15541258 PMID:19230594 PMID:24894748
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