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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:6887
Term: methylphenidate
Definition: A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
Chemical ID: MESH:D008774
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2affects expressionEXP 6480464CTDMethylphenidate affects the expression of DRD2 proteinPMID:17599397
Drd2multiple interactionsEXP 6480464CTD[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to MethylphenidatePMID:11454915
Drd2decreases expressionISODrd2 (Mus musculus)6480464CTDMethylphenidate results in decreased expression of DRD2 mRNAPMID:22470460 PMID:33647392
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