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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621504
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnq2
Name: potassium voltage-gated channel subfamily Q member 2
Acc ID: CHEBI:68584
Term: ezogabine
Definition: A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults.
Chemical ID: MESH:C101866
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnq2affects activityISOKCNQ2 (Homo sapiens)6480464CTDezogabine affects the activity of KCNQ2 proteinPMID:26627826
Kcnq2multiple interactionsISOKcnq2 (Mus musculus)6480464CTDezogabine affects the reaction [[Potassium results in increased activity of KCNQ2 protein] which results in increased import of Thallium]PMID:15634793
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