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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61799
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnq4
Name: potassium voltage-gated channel subfamily Q member 4
Acc ID: CHEBI:68584
Term: ezogabine
Definition: A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults.
Chemical ID: MESH:C101866
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnq4increases activityISOKCNQ4 (Homo sapiens)6480464CTDezogabine results in increased activity of KCNQ4 proteinPMID:16904708 PMID:21782781
Kcnq4multiple interactionsISOKCNQ4 (Homo sapiens)6480464CTD[ezogabine results in increased activity of KCNQ4 protein] which results in increased export of Rubidium; [ezogabine results in increased activity of KCNQ4 protein] which results in increased import of ThalliumPMID:21782781
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