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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:68444
Term: 1-methyl-7H-xanthine
Definition: A 1-methylxanthine tautomer where the imidazole proton is located at the 7-position.
Chemical ID: MESH:C053085
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTD1-methylxanthine results in decreased activity of CYP1A2 proteinPMID:11465391
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[CYP1A2 protein results in increased metabolism of 1,7-dimethylxanthine] which results in increased chemical synthesis of 1-methylxanthinePMID:19215233
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