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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631 Species: Homo sapiens RGD Object: Gene Symbol: CYP11A1 Name: cytochrome P450, family 11, subfamily A, polypeptide 1

Acc ID: CHEBI:6842 Term: methoxychlor Definition: An organochlorine insecticide that has formula C16H15Cl3O2. CasRN: 72-43-5 Chemical ID: MESH:D008731

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Methoxychlor results in increased expression of CYP11A1 mRNA	PMID:12858341
multiple interactions	ISO	RGD:69325	6480464	CTD	Methoxychlor metabolite inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]	PMID:16737795
affects activity	ISO	RGD:69325	6480464	CTD	Methoxychlor metabolite affects the activity of CYP11A1 protein	PMID:15336722
decreases activity	ISO	RGD:69325	6480464	CTD	Methoxychlor metabolite results in decreased activity of CYP11A1 protein	PMID:16199348
decreases expression	ISO	RGD:69325	6480464	CTD	Methoxychlor metabolite results in decreased expression of CYP11A1 mRNA	PMID:10684797
decreases activity	ISO	RGD:69325	6480464	CTD	Methoxychlor results in decreased activity of CYP11A1 protein	PMID:16226009
decreases expression	ISO	RGD:735632	6480464	CTD	Methoxychlor results in decreased expression of CYP11A1 mRNA	PMID:21514315
decreases expression	ISO	RGD:69325	6480464	CTD	Methoxychlor results in decreased expression of CYP11A1 protein	PMID:18848953