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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4decreases activityISOCYP2D6 (Homo sapiens)6480464CTDMethoxychlor results in decreased activity of CYP2D6 proteinPMID:18420780
Cyp2d4decreases methylationISOCYP2D6 (Homo sapiens)6480464CTDCYP2D6 protein results in decreased methylation of MethoxychlorPMID:12167570 PMID:12433799
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