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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731056 Species: Homo sapiens RGD Object: Gene Symbol: INS Name: insulin

Acc ID: CHEBI:6801 Term: metformin Definition: A guanidine that has formula C4H11N5. CasRN: 657-24-9 Chemical ID: MESH:D008687

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Metformin results in decreased expression of and results in decreased secretion of INS protein	PMID:18082302
decreases expression	EXP		6480464	CTD	Metformin results in decreased expression of INS protein	PMID:1900072
decreases expression	EXP		6480464	CTD	Metformin results in decreased expression of INS protein	PMID:1900072 PMID:21779873
decreases expression	EXP		6480464	CTD	Metformin results in decreased expression of INS protein	PMID:21779873 PMID:1900072
increases expression	EXP		6480464	CTD	Metformin results in increased expression of INS mRNA	PMID:15531508
multiple interactions	EXP		6480464	CTD	Metformin promotes the reaction [Glucose results in increased secretion of INS protein] Metformin results in increased expression of and results in increased secretion of INS protein	PMID:15531508