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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargaffects activityEXP 6480464CTDMetformin affects the activity of PPARG proteinPMID:25596134
Ppargincreases expressionEXP 6480464CTDMetformin results in increased expression of PPARG mRNAPMID:20724125
Ppargmultiple interactionsEXP 6480464CTDMetformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA]PMID:25108154 PMID:30256492
Ppargdecreases expressionISOPPARG (Homo sapiens)6480464CTDMetformin results in decreased expression of PPARG mRNAPMID:20956498
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDMetformin results in increased expression of PPARG mRNAPMID:21870829
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDMetformin inhibits the reaction [[cyhalothrin co-treated with Oleic Acid] results in increased expression of PPARG protein]; Metformin inhibits the reaction [INS protein results in increased expression of PPARG protein]PMID:36529352 PMID:36764371
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTDMetformin inhibits the reaction [IL13 protein results in increased expression of PPARG mRNA]PMID:26497364
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