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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1351828 Species: Homo sapiens RGD Object: Gene Symbol: SLC22A3 Name: solute carrier family 22 (extraneuronal monoamine transporter), member 3

Acc ID: CHEBI:6801 Term: metformin Definition: A guanidine that has formula C4H11N5. CasRN: 657-24-9 Chemical ID: MESH:D008687

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Metformin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]	PMID:16141367
multiple interactions	EXP		6480464	CTD	carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]	PMID:21697722
increases uptake	EXP		6480464	CTD	SLC22A3 protein results in increased uptake of Metformin	PMID:21697722