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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:67521
Term: (-)-gambogic acid
Definition: A pyranoxanthone that has formula C38H44O8.
Chemical ID: MESH:C052659
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9decreases expressionISOCASP9 (Homo sapiens)6480464CTDgambogic acid results in decreased expression of CASP9 protein alternative formPMID:19464570
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD[gambogic acid co-treated with Bortezomib] results in increased activity of CASP9 protein; [Verapamil co-treated with gambogic acid] results in increased cleavage of and results in increased activity of CASP9 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[gambogic acid co-treated with Bortezomib] results in increased activity of CASP9 protein]PMID:24291039 PMID:24373880
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