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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:6709
Term: Meclizine
Definition: A diarylmethane that has formula C25H27ClN2.
Chemical ID: MESH:D008468
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3increases activityEXP 6480464CTDMeclizine results in increased activity of NR1I3 protein alternative form; Meclizine results in increased activity of NR1I3 protein mutant formPMID:21778469
Nr1i3increases activityISONR1I3 (Homo sapiens)6480464CTDMeclizine results in increased activity of NR1I3 protein alternative formPMID:21778469
Nr1i3increases activityISONr1i3 (Mus musculus)6480464CTDMeclizine results in increased activity of NR1I3 protein alternative form; Meclizine results in increased activity of NR1I3 protein mutant formPMID:21778469
Nr1i3multiple interactionsISONR1I3 (Homo sapiens)6480464CTDMeclizine binds to and results in decreased activity of NR1I3 protein; Meclizine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein]; Meclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP1A2 mRNA]; Meclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP2B10 mRNA]; Meclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP3A11 mRNA]; Meclizine inhibits the reaction [NR1I3 protein binds to NCOA1 protein]PMID:15272053
Nr1i3multiple interactionsISONr1i3 (Mus musculus)6480464CTD[Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of ABCC2 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP1A2 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP2B10 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP3A11 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of GSTA1 mRNA; [Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of UGT1A1 mRNA; Meclizine binds to and results in increased activity of NR1I3 protein; Meclizine promotes the reaction [NR1I3 protein binds to NCOA1 protein]PMID:15272053
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