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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:6709
Term: Meclizine
Definition: A diarylmethane that has formula C25H27ClN2.
Chemical ID: MESH:D008468
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of CYP1A2 mRNAPMID:15272053
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDMeclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP1A2 mRNA]PMID:15272053
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