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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:6651 Term: malathion Definition: A carboxyalkyl phosphate that has formula C10H19O6PS2. CasRN: 121-75-5 Chemical ID: MESH:D008294

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects metabolic processing	EXP		6480464	CTD	CYP3A4 protein affects the metabolism of Malathion	PMID:15557345 PMID:17110060
affects metabolic processing	EXP		6480464	CTD	CYP3A4 protein affects the metabolism of Malathion	PMID:17110060 PMID:15557345
increases expression	EXP		6480464	CTD	Malathion results in increased expression of CYP3A4 mRNA	PMID:22310298