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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730821 Species: Homo sapiens RGD Object: Gene Symbol: MMP2 Name: matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Acc ID: CHEBI:6541 Term: losartan Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position CasRN: 114798-26-4 Chemical ID: MESH:D019808

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:621316	6480464	CTD	Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]	PMID:12930639
multiple interactions	ISO	RGD:621316	6480464	CTD	Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]	PMID:16251426