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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3194
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nppb
Name: natriuretic peptide B
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nppbincreases expression EXP 11526363RGDisoprenaline increases expression of mRNA in neonatal rat cardiomyocytes 
Nppbdecreases secretionEXP 6480464CTDIsoproterenol results in decreased secretion of NPPB protein modified formPMID:35940283
Nppbincreases expressionEXP 6480464CTDIsoproterenol results in increased expression of NPPB mRNA; Isoproterenol results in increased expression of NPPB proteinPMID:18806606 PMID:25045214 PMID:27890915 PMID:28816235 PMID:31009642 PMID:32686902 PMID:37528096 PMID:37611474 PMID:9043801
Nppbmultiple interactionsEXP 6480464CTD2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPB mRNA]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPB protein]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]]; N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; RELA mRNA promotes the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; swietenine inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; thymoquinone inhibits the reaction [Isoproterenol results in decreased secretion of NPPB protein modified form]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]PMID:18806606 PMID:25045214 PMID:27890915 PMID:28816235 PMID:31009642 PMID:32686902 PMID:35940283 PMID:37528096
Nppbincreases expressionISONppb (Mus musculus)6480464CTDIsoproterenol results in increased expression of NPPB mRNA; Isoproterenol results in increased expression of NPPB proteinPMID:11804996 PMID:31009642 PMID:32686902 PMID:37269933 PMID:37528096
Nppbincreases expressionISONPPB (Homo sapiens)6480464CTDIsoproterenol results in increased expression of NPPB mRNAPMID:34023961
Nppbmultiple interactionsISONppb (Mus musculus)6480464CTDbellidifolin inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; celastrol methyl ester inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]; swietenine inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]PMID:31009642 PMID:32686902 PMID:37269933 PMID:37528096
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