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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2926 Species: Rattus norvegicus RGD Object: Gene Symbol: Itgam Name: integrin, alpha M

Acc ID: CHEBI:64317 Term: isoprenaline Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders. CasRN: 7683-59-2 Chemical ID: MESH:D007545

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1343608	6480464	CTD	Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]]	PMID:9762784