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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2061
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb3
Name: adrenoceptor beta 3
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adrb3increases activityEXP 6480464CTDIsoproterenol results in increased activity of ADRB3 proteinPMID:17622774
Adrb3increases expressionEXP 6480464CTDIsoproterenol results in increased expression of ADRB3 mRNA; Isoproterenol results in increased expression of ADRB3 proteinPMID:15009959 PMID:20654104
Adrb3multiple interactionsEXP 6480464CTD3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Isoproterenol results in increased activity of ADRB3 protein]; 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Isoproterenol results in increased expression of ADRB3 protein]; BRL 37344 promotes the reaction [Isoproterenol results in increased expression of ADRB3 mRNA]; BRL 37344 promotes the reaction [Isoproterenol results in increased expression of ADRB3 protein]; Isoproterenol binds to and results in increased activity of ADRB3 proteinPMID:15009959 PMID:17622774 PMID:20654104 PMID:7815362
Adrb3increases activityISOADRB3 (Homo sapiens)6480464CTDIsoproterenol results in increased activity of ADRB3 proteinPMID:18553954 PMID:18820136
Adrb3multiple interactionsISOAdrb3 (Mus musculus)6480464CTD[ADRB3 affects the expression of ADRB1 mRNA] which affects the susceptibility to IsoproterenolPMID:11159692
Adrb3multiple interactionsISOADRB3 (Homo sapiens)6480464CTD[Isoproterenol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Isoproterenol binds to and results in increased activity of ADRB3 protein; Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB3 protein]; L 748,337 inhibits the reaction [Isoproterenol results in increased activity of ADRB3 protein]PMID:14730417 PMID:1682311 PMID:18820136
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