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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620944
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp7
Name: caspase 7
Acc ID: CHEBI:64312
Term: memantine
Definition: A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
Chemical ID: MESH:D008559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp7multiple interactionsISOCASP7 (Homo sapiens)6480464CTDMemantine inhibits the reaction [benzo(e)pyrene results in increased activity of CASP7 protein]; Memantine inhibits the reaction [catechol results in increased activity of CASP7 protein]PMID:19959636 PMID:20347921
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