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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551394 Species: Mus musculus RGD Object: Gene Symbol: Pon2 Name: paraoxonase 2

Acc ID: CHEBI:64294 Term: 7-ketocholesterol Definition: A cholestanoid that consists of cholesterol bearing an oxo substituent at position 7. CasRN: 566-28-9 Chemical ID: MESH:C003001

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	EXP		6480464	CTD	7-ketocholesterol results in increased activity of PON2 protein	PMID:12615656
increases expression	EXP		6480464	CTD	7-ketocholesterol results in increased expression of PON2 mRNA	PMID:12615656