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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347922 Species: Homo sapiens RGD Object: Gene Symbol: PCK1 Name: phosphoenolpyruvate carboxykinase 1 (soluble)

Acc ID: CHEBI:64227 Term: ciglitazone Definition: An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist. CasRN: 74772-77-3 Chemical ID: MESH:C039671

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[ciglitazone binds to PPARG protein alternative form] which results in increased expression of PCK1 mRNA [ciglitazone binds to PPARG protein] which results in increased expression of PCK1 mRNA	PMID:16197558