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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3913 Species: Rattus norvegicus RGD Object: Gene Symbol: Tst Name: thiosulfate sulfurtransferase

Acc ID: CHEBI:64215 Term: 2,3-dimethoxynaphthalene-1,4-dione Definition: A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis. CasRN: 6956-96-3 Chemical ID: MESH:C063002

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:735470	6480464	CTD	2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of TST mRNA	PMID:17547211