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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2055
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adra1a
Name: adrenoceptor alpha 1A
Acc ID: CHEBI:64203
Term: methiothepin
Definition: A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Chemical ID: MESH:D008719
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adra1amultiple interactionsEXP 6480464CTDMethiothepin binds to and results in decreased activity of ADRA1A proteinPMID:16545797
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