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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:64163
Term: diquat
Definition: The organic cation formed formally by addition of an ethylene bridge between the nitrogen atoms of 2,2'-bipyridine. Most often available as the dibromide.
Chemical ID: MESH:D004178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases expressionEXP 6480464CTDDiquat results in increased expression of CASP9 protein modified formPMID:29484840
Casp9multiple interactionsEXP 6480464CTDMeloxicam inhibits the reaction [Diquat results in increased expression of CASP9 protein modified form]PMID:29484840
Casp9increases cleavageISOCasp9 (Mus musculus)6480464CTDDiquat results in increased cleavage of CASP9 proteinPMID:20826540
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTDDiquat results in increased cleavage of and results in increased activity of CASP9 protein; PROP1 protein affects the reaction [Diquat results in increased cleavage of CASP9 protein]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP9 protein]PMID:18164269 PMID:20826540
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