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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473 Species: Mus musculus RGD Object: Gene Symbol: Nqo1 Name: NAD(P)H dehydrogenase, quinone 1

Acc ID: CHEBI:64163 Term: diquat Definition: The organic cation formed formally by addition of an ethylene bridge between the nitrogen atoms of 2,2'-bipyridine. Most often available as the dibromide. CasRN: 2764-72-9 Chemical ID: MESH:D004178

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Diquat results in increased expression of NQO1 mRNA	PMID:20826540
increases activity	ISO	RGD:735868	6480464	CTD	Diquat results in increased activity of NQO1 protein	PMID:21172416
increases expression	ISO	RGD:735868	6480464	CTD	Diquat results in increased expression of NQO1 mRNA Diquat results in increased expression of NQO1 protein	PMID:21172416
multiple interactions	EXP		6480464	CTD	PROP1 protein affects the reaction [Diquat results in increased expression of NQO1 mRNA]	PMID:20826540