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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736081 Species: Homo sapiens RGD Object: Gene Symbol: ADRA1A Name: adrenoceptor alpha 1A

Acc ID: CHEBI:64114 Term: GR 127935 Definition: A carboxamide obtained by formal condensation of the carboxy group of 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid and the anilino group of 4-methoxy-3-(4-methylpiperazin-1-yl)aniline. Potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration. CasRN: 148672-13-3 Chemical ID: MESH:C090701

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:2055	6480464	CTD	GR 127935 promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]	PMID:16545797