GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | affects localization | EXP | | 6480464 | CTD | 1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein | PMID:26048653 | Nfe2l2 | decreases localization | EXP | | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in decreased localization of NFE2L2 protein | PMID:22019741 | Nfe2l2 | increases expression | EXP | | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein | PMID:23272707 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; [1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of and affects the localization of NFE2L2 protein; [Luteolin results in increased activity of NFE2L2 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]; FYN protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of NFE2L2 protein]; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; Lithium Chloride inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased activity of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]]; Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased localization of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]] | PMID:17982879 PMID:22019741 PMID:23272707 PMID:26048653 PMID:32763437 | Nfe2l2 | decreases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 mRNA; 1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 protein | PMID:31187328 PMID:34967706 | Nfe2l2 | increases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 mRNA | PMID:30965670 | Nfe2l2 | increases response to substance | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | NFE2L2 gene mutant form results in increased susceptibility to 1-Methyl-4-phenylpyridinium | PMID:12842875 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | NFE2L2 protein promotes the reaction [Pioglitazone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]]; NFE2L2 protein promotes the reaction [Pioglitazone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]]; NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 mRNA]]; NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]]; NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]]; Pioglitazone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 mRNA]; Pioglitazone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 mRNA]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 mRNA]; tideglusib promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 mRNA] | PMID:30965670 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | [1-Methyl-4-phenylpyridinium co-treated with puerarin] affects the localization of NFE2L2 protein; [1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein; [baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] affects the localization of NFE2L2 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of and results in increased ubiquitination of NFE2L2 protein; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; cinnamaldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [[1-Methyl-4-phenylpyridinium co-treated with puerarin] results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]; SB 216763 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 protein] | PMID:31187328 PMID:32763437 PMID:38016618 | | ||||||||||||||||||||||
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