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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3852
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfbr1
Name: transforming growth factor, beta receptor 1
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfbr1increases expressionISOTgfbr1 (Mus musculus)6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of TGFBR1 mRNA; 1-Methyl-4-phenylpyridinium results in increased expression of TGFBR1 proteinPMID:34967706
Tgfbr1multiple interactionsISOTgfbr1 (Mus musculus)6480464CTDTGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 protein]]; TGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B protein]]; TGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]]; TGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]PMID:26254549
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