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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1decreases expressionEXP 6480464CTD1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 mRNA; 1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 proteinPMID:17583434 PMID:18538940 PMID:29631008 PMID:30712312 PMID:33204711
Sirt1increases expressionEXP 6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of SIRT1 proteinPMID:18538940
Sirt1multiple interactionsEXP 6480464CTD[1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of SIRT1 protein; [resveratrol co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of SIRT1 mRNAPMID:17583434 PMID:22742579
Sirt1decreases expressionISOSIRT1 (Homo sapiens)6480464CTD1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 mRNA; 1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 proteinPMID:25073091 PMID:26768367 PMID:28851138 PMID:36629037
Sirt1multiple interactionsISOSIRT1 (Homo sapiens)6480464CTD1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased activity of SIRT1 protein; chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein]; garcinol inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein]; rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased activity of SIRT1 protein]; SIRT1 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HIF1A mRNA]PMID:25073091 PMID:26768367 PMID:28851138 PMID:36629037
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