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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2decreases activityISOCDK2 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in decreased activity of CDK2 proteinPMID:12766906
Cdk2decreases expressionISOCDK2 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in decreased expression of CDK2 mRNAPMID:15336504
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTDginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CDK2 protein]PMID:15606011
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