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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDtert-Butylhydroperoxide results in decreased activity of GSR proteinPMID:15212457 PMID:16928893
Gsrmultiple interactionsEXP 6480464CTDPlant Extracts inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of GSR protein]PMID:15212457
Gsrdecreases expressionISOGsr (Mus musculus)6480464CTDtert-Butylhydroperoxide results in decreased expression of GSR mRNAPMID:14729362
Gsrdecreases methylationISOGSR (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in decreased methylation of GSR genePMID:27509014
Gsrincreases activityISOGSR (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in increased activity of GSR proteinPMID:15336504 PMID:15849717 PMID:16126241 PMID:17427263
Gsrincreases activityISOGsr (Mus musculus)6480464CTDtert-Butylhydroperoxide results in increased activity of GSR proteinPMID:15003993
Gsrincreases expressionISOGSR (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in increased expression of GSR mRNAPMID:23410634 PMID:27509014
Gsrmultiple interactionsISOGSR (Homo sapiens)6480464CTDQuercetin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GSR protein]PMID:16126241
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