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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620525
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mcl1
Name: MCL1 apoptosis regulator, BCL2 family member
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mcl1decreases response to substanceISOMCL1 (Homo sapiens)6480464CTDMCL1 protein results in decreased susceptibility to tert-ButylhydroperoxidePMID:15611089
Mcl1multiple interactionsISOMCL1 (Homo sapiens)6480464CTD[HIF1A protein results in increased expression of MCL1 protein] which results in decreased susceptibility to tert-Butylhydroperoxide; MCL1 protein inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]PMID:15611089
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