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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in increased expression of VEGFA mRNA; tert-Butylhydroperoxide results in increased expression of VEGFA proteinPMID:15336504 PMID:17200665 PMID:20847119
Vegfaincreases secretionISOVEGFA (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in increased secretion of VEGFA proteinPMID:17200665
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of VEGFA mRNA; [Pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of VEGFA mRNA; [Rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of VEGFA mRNA; [Troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of VEGFA mRNA; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of VEGFA mRNA]; Pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of VEGFA mRNA]; Rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of VEGFA mRNA]; Troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of VEGFA mRNA]PMID:20847119 PMID:35690295
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