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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10681 Species: Mus musculus RGD Object: Gene Symbol: Gpx1 Name: glutathione peroxidase 1

Acc ID: CHEBI:64090 Term: tert-butyl hydroperoxide Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes. CasRN: 75-91-2 Chemical ID: MESH:D020122

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases reduction	ISO	RGD:737005	6480464	CTD	GPX1 protein results in increased reduction of tert-Butylhydroperoxide	PMID:8428933
decreases response to substance	EXP		6480464	CTD	GPX1 protein results in decreased susceptibility to tert-Butylhydroperoxide	PMID:9741587
increases response to substance	EXP		6480464	CTD	GPX1 gene mutant form results in increased susceptibility to tert-Butylhydroperoxide	PMID:15182862
increases expression	ISO	RGD:2729	6480464	CTD	tert-Butylhydroperoxide results in increased expression of GPX1 mRNA	PMID:19720132