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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2518
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd1
Name: dopamine receptor D1
Acc ID: CHEBI:64078
Term: (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride
Definition: A hydrochloride salt obtained by mixing equimolar amounts of (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol with hydrochloric acid. Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo.
Chemical ID: MESH:C079415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd1affects localizationISODRD1 (Homo sapiens)6480464CTDA 77636 affects the localization of DRD1 proteinPMID:15985612
Drd1multiple interactionsISODRD1 (Homo sapiens)6480464CTDA 77636 binds to and results in increased activity of DRD1 protein; SCH 23390 inhibits the reaction [A 77636 affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [A 77636 results in increased activity of DRD1 protein]PMID:15985612
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